NeoCor Products

	UniLine - Atrioventricular Xenopericardial Heart Valve Bioprostheses
	UniLine - Aortic Xenopericardial Heart Valve Bioprostheses
	TiAra - New Bioprosthesis of Aortic Heart Valve
	KemPeriplas - Xenopericardial Patches for Surgical Reconstruction
	Pilon - Xenopericardial Cardiac Valved Conduit
	МСP - Xenopericardial Monoleaflet Cardiac Prosthesis
	KemAngioprotez - Vascular Graft Bioprosthesis
	Biological support ring for tricuspid valve annuloplasty

Production Archive:

PeriCor - Porcine Bioprosthesis

AB-Compozit Neo - Aortic Heart Valve Bioprosthesis 

Technology

Laser cut-out of biological tissue

In 2007, an automated laser system to cut out xenopericardium was set put into operation. To date, it remains unparalleled and allows to maximize the quality of the xenograft.
This laser unit produces an automatic, high accuracy cut-outs of all the elements of a biological prosthesis to meet the requirements of the most exacting customers.

Advantages

• • Measurement of tissue thickness, topographic mapping to represent xenopericardium thickness.
• • Automatic template setting to match the billet thickness, precision cut-out to 10 microns.
• • Laser cut-out technology prevents collagen fiber garneting along the cutting edge and thus maintainsthe structure of biomaterial.
• • Laser impulse frequency and radiation power produce an even “soldered” tissue edge.

Scissor cut-out	Scalpel cut-out	Laser cut-out

Preservation of biological prostheses

NeoCor biological prostheses preserved with epoxy compounds have a number of advantages as compared to their analogues.

• High resistance to calcification1. Bioprosthesis PeriCor with that tissue treatment demonstrate longterm follow-up data showed freedom from calcification by 97% at 9 year.
• Diepoxy-treated xenopericadium is stronger than treated with glutaraldehyde.
• It’s marked hydrophilic nature results in 10% elasticity increase, so its biomechanical properties are nearing those of native material.
• Preservation with diepoxy compound renders biomaterial highly biocompatible and enhances its hydrodynamic properties.
• Preservation with epoxy compounds imparts to the biomaterial protection from a number pathogens including retroviruses.

New patented Neocor storage solution

Storage in the new sterilizing solution allows to maintain the properties of biomaterial and shorten the rinse time to 15 min..

Additional treatments of bioprostheses

• Antibacterial activity of the biomaterials is due to chlorhexidine immobilization that deduces contamination with various microbes. The technology is authorized by the Russian Ministry of Public Health.
• Anticalcification modification. Diphosphonate immobilization inhibits the biomaterial calcification and does not cause destructive changes in the epoxy-treated tissue. The process preserves the elastic properties of the tissue and enhances its strength by 56%.7,6
• Antithrombotic modification. Additional treatment with various heparins imparts high thrombosis resistance to the biomaterial.